The recent escalation of hostilities in the occupied Palestinian territory (oPt) is taking a heavy toll on civilians. Thousands have been killed or injured, and over 1.4 million people have been displaced. There have been 171 attacks on health care in oPt leading to 493 deaths and 387 injuries, with 56 attacks impacting health facilities and 130 impacting health personnel, as of 24 October 2023. The health system is on the verge of collapse and dwindling access to health services, clean water, food and fuel on top of an already weakened healthcare system risks further loss of civilian life. Massive displacement to shelters with inadequate resources will result in disease outbreaks. The escalation of hostilities has already spread to the West Bank, East Jerusalem, the Lebanon Israel border and Syrian Arab Republic, with a risk of spilling over to other countries in the region, including Jordan, the Islamic Republic of Iran, and Iraq.